Research Studies

  A Pivotal Randomized, Parallel Evaluation of rhBMP-2/Absorbable Collagen Sponge and Bone Graft for Maxillary Sinus Floor Augmentation. Recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) is an investigational product developed by Genetics Institute and is being evaluated for use where patients have lost bone in the back (maxillary sinus) of their upper jaw. rhBMP-2 is a protein that is very similar to proteins involved in bone growth that are already found in your

body. The absorbable collagen sponge (ACS) is a sterilized product that is made from the tendons of cows and acts as a carrier to supply the rhBMP-2 to the area where you want bone to grow. The carrier is absorbable, which means that it will slowly dissolve in the body. When studied in humans and animals, rhBMP-2/ACS has grown bone.



The Reality of Immediate Implant Placement

The success of endosteal implants in edentulous patients was followed by the successful use of these implants in partially edentulous patients. The past decade has seen the development of a variety of unique implant designs to facilitate replacement of individual lost teeth. As single tooth replacement with implants became part of the dental standard of care it was only logical that interest would focus on the issues associated with immediate implant placement. The positive, psychological impact of immediate placement is clear. The sense of loss due to extraction of a tooth is minimized by the positive aspect of immediate placement with the realization that the patient is on their was to being whole again.



Craniofacial Research Joint program between the Department of Orthodontics and the Center for Craniofacial Disorders

Objectives:
Development of a comprehensive, interdisciplinary database of all craniofacial patients seen at the Center for Craniofacial Disorders (over 8,000). This database will be fully integrated with departmental computerized charts allowing for more efficient communication between clinicians. The searchable functionality will allow for extensive data retrieval and research studies.

A descriptive study will be performed in order to elucidate clinical characteristics of patients seen at the Center for Craniofacial Disoders. This will include anatomy, type and location of cleft(s), malformed/missing dentition, feeding status, initial speech analysis, and the presence of other medical conditions.

Data from orthodontics, oral and maxillofacial surgery, plastic surgery, pediatric neurosurgery, otolaryngology and speech pathology departments will be collected and analyzed in order to perform a treatment outcomes assessment study. Specifically, of interest is the long-term impact on maxillofacial growth and speech of the various treatment techniques, sequences and protocols used at the Center.
An epidemiological study will be conducted based on demographic data that will include age of parents at time of conception, location of residence, ethnicity, genetic, medical, social, economic and behavioral factors. The goal of these studies is to identify risk factors and promote behavioral and health promotion topics as they relate to craniofacial anomaly prevention in the Metropolitan New York City area.

Mentors: Anthony Maganzini, DDS, MSD
Director of Orthodontics, Montefiore Medical Center
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Alan Shanske, MD
Director, Center for Craniofacial Disorders, Children's Hospital at Montefiore
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Principal Investigator:
Mairaj Ahmed, DDS
Fellow, Department of Orthodontics
Clinical Research Methods Certificate Program

Mairaj Ahmed, DDS
Fellow
Center for Craniofacial Disorders,
Children's Hospital at Montefiore & Department of Orthodontics,
Montefiore Medical Center
111 E. 210th St., Bronx, NY, 10467
Office: 718-920-2382
Fax: 718-515-5419
Cell Phone: 585-739-4587
maiahmed@montefiore.org

Other Research Team Members:
Xin Zheng, PhD
Director, Bioinformatics Shared Resource
Assistant Professor of Pathology
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Paul Levy, MD
Assistant Professor of Pediatrics and Pathology
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Collaborators:
Robert Shprintzen, PhD
Eileen Marrinan, MS, MPh
Central New York Cleft & Craniofacial Center
Velo-Cardio-Facial Syndrome (VCFS) Center
SUNY - Upstate Medical University Hospital
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Charlotte Druschel, MD, MPH
Medical Director, Congenital Malformations Registry
New York State Department of Health
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If you have any questions or would like to support this effort, please email:
maiahmed@montefiore.org





 
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